If you're project is small to medium in size and you want to produce something quickly I would suggest you use django. If your project is large and complex and you need something extremely flexible then I would suggest you use pylons.
Pyroxide is a python web application framework built atop Apache's mod_python. It uses the MVC (model-view-controller) pattern and other classic object oriented patterns throughout. It abstracts the mod_python layer presenting a very sensible object oriented framework so that the developer deals with HTTP Requests, HTTP Responses, Page Controllers, Views and domain model objects. It integrates very well with AJAX frameworks such as Prototype and Mochikit. What makes pyroxide special is its industrial strength, built-in ORM (Object-Relational Mapping) layer.