Pyroxide is a python web application framework built atop Apache's mod_python. It uses the MVC (model-view-controller) pattern and other classic object oriented patterns throughout. It abstracts the mod_python layer presenting a very sensible object oriented framework so that the developer deals with HTTP Requests, HTTP Responses, Page Controllers, Views and domain model objects. It integrates very well with AJAX frameworks such as Prototype and Mochikit. What makes pyroxide special is its industrial strength, built-in ORM (Object-Relational Mapping) layer.
Until I have time to create a proper web page, please see the Trac wiki and source repository for documentation. You can also browse the pyroxide API documentation.
And if proof is in the pudding, the socially generated community directory site called lokl.com is entirely built with the pyroxide framework.